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All Publications

Nature. 2022

Cerullo F, Filbeck S, Patil PR, Hung HC, Xu H, Vornberger J, Hofer FW, Schmitt J, Kramer G, Bukau B, Hofmann K, Pfeffer S, Joazeiro CAP.

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue

Mol Cell. 2022

Filbeck S, Cerullo F, Pfeffer S, Joazeiro CAP.

Ribosome-associated quality-control mechanisms from bacteria to humans

Mol Cell. 2021

Thrun A, Garzia A, Kigoshi-Tansho Y, Patil PR, Umbaugh CS, Dallinger T, Liu J, Kreger S, Patrizi A, Cox GA, Tuschl T, Joazeiro CAP.

Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. 

Mol Cell. 2021

Filbeck S, Cerullo F, Paternoga H, Tsaprailis G, Joazeiro CAP, Pfeffer S.

Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC. 

Nat Commun. 2020

Martin PB, Kigoshi-Tansho Y, Sher RB, Ravenscroft G, Stauffer JE, Kumar R, Yonashiro R, Müller T, Griffith C, Allen W, Pehlivan D, Harel T, Zenker M, Howting D, Schanze D, Faqeih EA, Almontashiri NAM, Maroofian R, Houlden H, Mazaheri N, Galehdari H, Douglas G, Posey JE, Ryan M, Lupski JR, Laing NG, Joazeiro CAP, Cox GA.

NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease. 

Cell. 2019

Lytvynenko I, Paternoga H, Thrun A, Balke A, Müller TA, Chiang CH, Nagler K, Tsaprailis G, Anders S, Bischofs I, Maupin-Furlow JA, Spahn CMT, Joazeiro CAP.

Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control. 

Proc Natl Acad Sci U S A. 2016

Doamekpor SK, Lee JW, Hepowit NL, Wu C, Charenton C, Leonard M, Bengtson MH, Rajashankar KR, Sachs MS, Lima CD, Joazeiro CA.

Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits. 

Elife. 2016

Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay SA, Craig EA, Mogk A, Bukau B, Joazeiro CA.

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. 

FEBS Lett. 2014

Satoh T, Sumiyoshi A, Yagi-Utsumi M, Sakata E, Sasakawa H, Kurimoto E, Yamaguchi Y, Li W, Joazeiro CA, Hirokawa T, Kato K.

Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity. 

Proc Natl Acad Sci U S A. 2014

Lyumkis D, Oliveira dos Passos D, Tahara EB, Webb K, Bennett EJ, Vinterbo S, Potter CS, Carragher B, Joazeiro CA.

Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex. 

J. Cell Biol. 2014

Ossareh-Nazari B, Niño CA, Bengtson MH, Lee JW, Joazeiro CA, Dargemont C.

Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy. 

Proc Natl Acad Sci U S A. 2013

Lyumkis D, Doamekpor SK, Bengtson MH, Lee JW, Toro TB, Petroski MD, Lima CD, Potter CS, Carragher B, Joazeiro CA.

Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase. 

Hum Mol Genet. 2011

Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M.

Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. 

Proc Natl Acad Sci U S A. 2009

Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA.

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. 

Annu Rev Biochem. 2009

Deshaies RJ, Joazeiro CA.

RING domain E3 ubiquitin ligases. 

PLoS One. 2008

Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, Chanda SK, Batalov S, Joazeiro CA. 

Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. 

Cancer Res. 2006

Joazeiro CA, Anderson KC, Hunter T.

Proteasome inhibitor drugs on the rise. 

Am Chem Soc. 2006

Zhang Q, Liu Y, Gao F, Ding Q, Cho C, Hur W, Jin Y, Uno T, Joazeiro CA, Gray N.

Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. 

Mol Cell. 2005

Takagi Y, Masuda CA, Chang WH, Komori H, Wang D, Hunter T, Joazeiro CA, Kornberg RD.

Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. 

Methods Enzymol. 2005

Li W, Chanda SK, Micik I, Joazeiro CA.

Methods for the functional genomic analysis of ubiquitin ligases. 

Proc Natl Acad Sci U S A. 2003

Donaldson KM, Li W, Ching KA, Batalov S, Tsai CC, Joazeiro CA.

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates. 

Mol Cell. 2003

Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel JP.

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. 

Nat Immunol. 2002

Fang D, Elly C, Gao B, Fang N, Altman Y, Joazeiro C, Hunter T, Copeland N, Jenkins N, Liu YC.

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. 

Nat Cell Biol. 2001

Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY.

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. 

J. Biol Chem. 2000

Qiu L, Joazeiro C, Fang N, Wang HY, Elly C, Altman Y, Fang D, Hunter T, Liu YC.

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. 

Mol Biol Cell. 2000

Leverson JD, Joazeiro CA, Page AM, Huang Hk, Hieter P, Hunter T.

The APC11 RING-H2 finger mediates E2-dependent ubiquitination. 

Science. 1999

Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC.

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. 

Braz J Med Biol Res. 1995

Geiduschek EP, Bardeleben C, Joazeiro CA, Kassavetis GA, Whitehall S.

Yeast RNA polymerase III: transcription complexes and RNA synthesis. 

NY: Raven Press; 1994

Kassavetis GA, Bardeleben C, Braun B, Joazeiro CA, Pisano M, Geiduschek EP.

Transcription by RNA polymerase III

Proc Natl Acad Sci U S A. 1991

Cassill JA, Whitney M, Joazeiro CA, Becker A, Zuker CS.

Isolation of Drosophila genes encoding G protein-coupled receptor kinases. 

Arch Biol Med Exp. 1988

Armelin MC, Joazeiro CA, Rocha KM, Armelin HA.

Generation of myc/fos transfectant Balb-3T3 cell lines. 

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